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Table 3 Patient’s characteristics and measurements of infratentorial structures

From: MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy

 

Healthy control subjects

All patients

  

Subtype

  
 

(n = 30)

(n = 86)

p valueb

SCA (n = 34)

CCA (n = 18)

MSA (n = 34)

p valuec

Age (years)

64.2 ± 18.7

60.5 ± 10.7

0.001

57.0 ± 12.0

65.2 ± 10.7

61.3 ± 8.1

0.027

Male sex

15 (50 %)

48 (55.8 %)

0.526

19 (55.9 %)

7 (38.9 %)

22 (64.7 %)

0.284

Body height (cm)

163.5 ± 6.7

160.4 ± 8.2

0.285

161.1 ± 8.6

156.9 ± 7.9

161.5 ± 7.7

0.124

Body weight (kg)

64.2 ± 18.7

57.3 ± 10.7

0.039

57.1 ± 10.8

57.9 ± 11.7

57.2 ± 10.3

0.959

MRI measurement

 Cranial AP diameter (mm)

181.6 ± 10.8

184.7 ± 9.3

0.074

184.1 ± 9.3

181.2 ± 11.7

187.1 ± 7.2

0.086

 Posterior cranial fossa volume (ml)

274.0 ± 26.7

260.0 ± 30.0

0.815

264.7 ± 33.8

252.6 ± 20.2

259.3 ± 29.1

0.377

 Midbrain AP diameter (mm)

15.1 ± 1.9

15.0 ± 2.0

0.711

14.9 ± 1.9

16.1 ± 1.9

14.5 ± 1.9

0.017

 Pons AP diameter (mm)

22.77 ± 1.5

14.9 ± 2.0

0.711

15.1 ± 1.8

14.6 ± 1.9

15.1 ± 2.3

0.723

 Pons transverse diameter (mm)

28.4 ± 4.3

26.4 ± 3.4

0.394

26.9 ± 2.5

29.4 ± 3.1

24.4 ± 3.0

0.001

 Cerebellar height (mm)

55.5 ± 3.3

47.1 ± 6.1

0.000

48.4 ± 50

47.8 ± 6.4

45.6 ± 6.7

0.152

 Cerebellar volume (ml)

117.6 ± 13.7

82.7 ± 16.6

0.192

83.4 ± 16.6

84.9 ± 16.2

78.8 ± 16.5

0.217

Correction for cranial sizea

 Corrected Midbrain AP diameter

0.083 ± 0.010

0.081 ± 0.011

0.417

0.081 ± 0.010

0.089 ± 0.011

0.078 ± 0.011

0.002

Corrected Pons AP diameter

0.126 ± 0.008

0.083 ± 0.011

0.417

0.082 ± 0.010

0.081 ± 0.013

0.081 ± 0.011

0.928

 Corrected Pons transverse diameter

0.157 ± 0.024

0.144 ± 0.024

0.406

0.146 ± 0.015

0.163 ± 0.020

0.131 ± 0.018

0.001

 Corrected Cerebellar height diameter

0.306 ± 0.023

0.256 ± 0.038

0.005

0.264 ± 0.030

0.265 ± 0.042

0.245 ± 0.040

0.061

 Corrected Cerebellar volume diameter

0.65 ± 0.06

0.49 ± 0.09

0.011

0.46 ± 0.09

0.47 ± 0.09

0.42 ± 0.09

0.100

Disease duration (years)

---

7.6 ± 6.4

 

10.5 ± 8.0

8.2 ± 4.6

4.1 ± 2.7

0.001

ICARS score

 Total score

---

36.7 ± 15.3

 

35.7 ± 12.1

31.4 ± 11.3

40.5 ± 19.0

0.206

 Domain I

---

15.0 ± 7.3

 

13.7 ± 6.4

10.7 ± 5.5

18.5 ± 7.6

0.001

 Domain II

---

16.5 ± 8.5

 

16.4 ± 6.3

15.4 ± 6.6

17.11 ± 1.1

0.800

 Domain III

---

3.21 ± 0.5

 

2.9 ± 1.1

3.2 ± 1.7

3.4 ± 1.7

0.468

 Domain IV

---

1.81 ± 0.3

 

1.9 ± 1.4

1.8 ± 1.3

1.6 ± 1.3

0.263

  1. SCA indicates spinocerebellar ataxia; CCA, cortical cerebellar atrophy; MSA, multiple system atrophy
  2. a each factor was divided by the cranial AP diameter
  3. b All patients vs. healthy control subjects (unpaired Student’s t-test and χ2 test)
  4. c one-way analysis of variance for the continuous variables and Kruskal-Wallis test for the ICARS score. χ2 test for the male sex distribution
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Cerebellum & Ataxias

ISSN: 2053-8871