Table 2 Demographic features and results of cross-sectional imaging analysis using MRI planimetry

Number

5

14

8

32

17

15

8

M: F ratio

5: 0

8: 6

8: 0

17: 15

17: 0

8: 7

8: 0

Age at disease onset

63.6 ± 8.2 (52–73)

57.6 ± 7.8

(40–70)

p = 0.191

54.6 ± 8.0

(40–65)

p = 0.101

66.0 ± 6.2

(53–79)

p = 0.462

67.0 ± 5.2

(55–75)

p = 0.302

72.1 ± 8.2

(60–87)

p = 0.074

67.9 ± 7.5

(60–85)

p = 0.396

Age at MRI

74.0 ± 11.3 (61–85)

68.4 ± 13.5 (44–87)

p = 0.415

65.3 ± 14.9 (44–87)

p = 0.285

74.4 ± 6.0 (61–83)

p = 0.936

75.7 ± 5.3 (66–83)

p = 0.758

76.7 ± 7.7 (62–89)

p = 0.546

72.8 ± 7.8 (62–88)

p = 0.817

Disease duration at MRI (year)

10.4 ± 6.8 (4–21)

10.7 ± 8.2 (2–30)

p = 0.889

10.6 ± 9.5 (2–30)

p = 0.711

8.4 ± 3.8 (3–18)

p = 0.562

8.7 ± 3.5 (3–17)

p = 0.664

4.7 ± 3.1 (1–11)

p = 0.028^a

4.9 ± 3.3 (1–10)

p = 0.047^a

Midbrain area (mm²)

88.8 ± 15.2 (71.9–105.2)

122.2 ± 24.7 (82.7–172.6)

p = 0.012^a

122.0 ± 30.6 (82.7–172.6)

p = 0.048^a

113.3 ± 17.1 (72.1–147.3)

p = 0.005^a

114.1 ± 15.6 (88.7–141.7)

p = 0.005^a

67.6 ± 14.8 (40.9–96.3)

p = 0.013^a

62.8 ± 10.9 (40.9–73.8)

p = 0.004^a

Pons area (mm²)

512.5 ± 46.0 (455.2–566.9)

500.9 ± 43.8 (408.0–572.9)

p = 0.620

514.7 ± 41.8 (459.8–572.9)

p = 0.931

508.5 ± 63.1 (370.5–676.4)

p = 0.890

535.6 ± 66.7 (418.0–676.4)

p = 0.481

446.2 ± 46.8 (354.3–510.4)

p = 0.013^a

458.0 ± 41.6 (381.7–510.4)

p = 0.049^a

Cerebellum area (mm²)

622.7 ± 96.8 (501.8–732.0)

628.8 ± 102.2 (449.0–812.8)

p = 0.909

649.9 ± 92.6 (510.3–812.8)

p = 0.623

M/P area ratio

0.173 ± 0.023 (0.148–0.202)

0.244 ± 0.047 (0.180–0.333)

p = 0.005^a

0.235 ± 0.049 (0.180–0.333)

p = 0.022^a

0.224 ± 0.031 (0.146–0.296)

p = 0.001^a

0.215 ± 0.027 (0.146–0.251)

p = 0.006^a

0.151 ± 0.026 (0.107–0.210)

p = 0.111

0.137 ± 0.017 (0.107–0.157)

p = 0.007^a

C/P area ratio

1.214 ± 0.142 (1.034–1.395)

1.255 ± 0.176 (0.927–1.591)

p = 0.639

1.278 ± 0.174 (1.119–1.613)

p = 0.502