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Table 1 Therapeutic strategies tested in Drosophila model of polyQ diseases

From: Alleviating neurodegeneration in Drosophila models of PolyQ diseases

Therapeutic strategy Functional mechanism Drosophila model Therapeutic result Reference
RNAi Inhibiting formation of polyQ-expanded protein SCA1, SCA3, HD Positive Mallik et al. [50]
Cystamine reducing Huntingtin (Htt) aggregation HD Positive Apostol et al. [51]
Agrawal et al. [52]
Bortvedt et al. [53]
Methylene blue (MB) Inhibiting Htt aggregation HD Positive Sontag et al [54]
18b-glycyrrhetinic acid Inhibiting Htt aggregation HD Positive Schulte et al. [55]
Camptothecins Inhibiting Htt aggregation HD Positive Schulte et al. [55]
OH-camptothecin Inhibiting Htt aggregation HD Positive Schulte et al. [55]
Carbenoxolone Inhibiting Htt aggregation HD Positive Schulte et al. [55]
Polyglutamine binding peptide 1 (QBP1) Inhibiting polyQ aggregation SCA3/MJD Positive Nagai et al. [56]
P42 Inhibiting polyQ-hHtt aggregation HD Positive Arribat et al. [57]
Hsp70 Reversing toxic structure of polyQ-expanded proteins SCA3/MJD, SBMA Positive Warrick et al [58]
Wang et al [59]
Hsp40 Reversing toxic structure of polyQ-expanded proteins HD Positive Kazemi et al [49]
Kuo et al. [60]
Hsp110 Reversing toxic structure of polyQ-expanded proteins HD Positive Kuo et al. [60]
Hsp22 Reversing toxic structure of polyQ-expanded proteins SCA3/MJD Positive Li et al. [61]
Rapamycin Accelerating toxic proteins degradation HD Positive but various side-effects on human Ravikumar et al. [62]
Morrisett et al. [63]
Letavernier et al. [64]
Kuypers et al. [65]
Maroto et al. [66]
Lithium chloride (LiCl) Accelerating toxic proteins degradation SCA3/MJD Positive Jia et al. [67]
Normal ataxin-3 Accelerating toxic proteins degradation SCA3/MJD Positive Warrick et al. [68]
Hsp104 Accelerating toxic proteins degradation SCA3/MJD Positive Cushman et al. [69]
Sodium butyrate Transcriptional regulation HD Positive Steffan et al. [70]
Suberoylanilide hydroxamic acid (SAHA) Transcriptional regulation HD Positive Steffan et al. [70]
Trichostatin A (TSA) Transcriptional regulation SCA3/MJD Positive Jung et al. [71]
Valproic acid (VPA) Transcriptional regulation SCA3/MJD Positive Yi et al. [72]
Myc Transcriptional regulation SCA3/MJD Positive Singh et al. [73]
Uncoupling proteins (UCPs) Ameliorating mitochondrial dysfunctions HD Positive Besson et al. [74]
Meclizine Ameliorating mitochondrial dysfunctions HD Positive Gohil et al. [75]