Fig. 2

Graphical representation of network analysis. Blue circles represent SARA items, light purple circles are the clinical variables and variables taken from neurological examination are in light pink. Lines represent correlations between two parameters (green for positive and red for negative correlation). The wider the line joining two variables, the more closely correlated these two variables. For this analysis, gender has been transformed into a numerical variable (1 = woman, 0 = man) and has been accordingly represented by WOM. Number of repeats in the expanded allele (REP) and age at onset (ONS) are highly correlated in negative way. Women show a more altered gait, left alternating movement and right finger-to-nose. Disease duration (EVO) is positively associated with right and left alternating movements (RAM and LAM), gait (GAI), stance (STA –not clearly visible in the plot–) and right finger-to-finger (RFF). SARA items (blue) are densely interconnected with each other forming a clear merging main domain. The presence of visual abnormalities in DaTSCAN SPECT imaging (DAT) has a positive relation with right and left alternating movements (RAM and LAM). The presence of decreased patellar reflexes (DPR) has a positive correlation with right finger-nose test (RFN) and right heel-shin slide (RHS), and is positively correlated with the age at onset of disease (ONS) and the degree of polyneuropathy (PNP). The other clinical variables (pyramidal signs, clinical extrapyramidal affection and the presence of polyneuropathy) are independent of cerebellar dysfunction expressed by SARA items