Acetyl-DL-leucine improves gait variability in patients with cerebellar ataxia—a case series

Table 2 Patient characteristics, categorized by patient number, gender, age, etiology, duration of disease, neuro-ophthalmological findings, participation in a previous case study [3] as well a clinical outcome scores before and under treatment with Acetyl-DL-leucine

ID	Age	ataxia type	duration	neuro-ophthalmological findings	SARA pre	SARA post	Study
ID	gender	ataxia type	duration	neuro-ophthalmological findings	SARA pre	SARA post	Strupp et al. 2013 [3]
1	73, m	SAOA	>24	8	12.5	9.5
2	57, w	ADA	>120	1, 3	8.0	6.0	X
3	73, w	SAOA	24	1, 2, 4	20.0	15.0
4	54, w	MSA-C	36	1, 2, 5, 8	13.0	12.0
5	59, m	SCA 2	56	1, 2, 7, slow saccades	16.0	12.5
6	23, m	SCA 2	36	1, 2, 7, slow saccades	13.0	9.0	X
7	68, w	ADA	>120	1, 2, 3, 6, 7, 8, hypometric saccades	17.0	11,0	X
8	60, m	SAOA	24	1, 6	14.0	12.5	X
9	68, w	MSA-C	36	1, 2	10,0	9.5
10	54, m	SAOA	60	1, 2, 6, 8	12.0	9.5
11	63, w	SAOA	>120	1, 2, 3, 4, 6, 7	14.5	12.5	X
12	51, m	SAOA	36	1, 2, 3, 6, 7 hypometric saccades	14.0	12.0	X
13	51, w	EA 2	24	1	17.0	16.0
14	49, m	SAOA	36	1, 2, 6, 7	16.5	15.5
15	63, w	SAOA	>120	1, 2, 3, 4, 6, 7	11.5	7.0	X
16	67, m	SAOA	48	1, 2, 4	13.5	11.5
17	60, m	SAOA	36	1, 3, 5, 8	16.0	12.5
18	47, w	SCA 1	36	1, 2, 5 (bilateral), 6, 7, hypermetric saccades	17.0	9.5	X

Legend: Abbrevations: m man, w woman, SCA spino cerebellar ataxia, EA 2 episodic ataxia type 2, MSA-C multiple system atrophy with cerebellar features, SAOA sporadic adult-onset ataxia of unknown etiology, ADA autosomal dominant cerebellar ataxia, 1 saccadic smooth pursuit, 2 gaze-evoked nystagmus, 3 head-shaking nystagmus, 4 rebound nystagmus, 5 pathological head-thrust test (uni- or bilateral), 6 impaired visual fixation suppression of the VOR, 7 pathological optokinetic reflex, 8 downbeat nystagmus

ISSN: 2053-8871