Fig. 1
From: Cerebellar fastigial nucleus: from anatomic construction to physiological functions
Organization of FN afferent pathways. The inhibitory GABAergic Purkinje axons constitute the most primary FN afferent pathway (blue). Two major types of afferents of the cerebellar circuitry, the climbing fibers from the inferior olive and the mossy fibers from the nucleus reticularis tegmenti pontis, the medullary reticular formation, and the medial vestibular nucleus send excitatory glutamatergic collaterals to FN (red). In addition, FN also receives serotonergic projections from the medullary/pontine reticular formation and the raphe nuclei (yellow) as well as histaminergic and orexinergic afferents from the hypothalamus (green). CF, climbing fiber; FN, fastigial nucleus; IO, inferior olive; MF, mossy fiber; MRF, medullary reticular formation; NRTP, nucleus reticularis tegmenti pontis; PC, Purkinje cell; PRF, pontine reticular formation; RN, raphe nuclei