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Table 5 Correlation coefficients between ICARS scores and two MRI biomarkers according to the subtypes of cerebellar ataxia

From: MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy

  ICARS total score    ICARS domain I  
Subtype n Cerebellar volume p value Midbrain AP diameter p value Cerebellar volume p value Midbrain AP diameter p value
SCA all patients 34 −0.306 0.079 −0.176 0.319 −0.340 0.049 −0.168 0.342
SCA1 3 ---- ---- ---- ---- ---- ---- ---- ----
SCA2 3 ---- ---- ---- ---- ---- ---- ---- ----
SCA3 7 −0.068 0.885 −0.279 0.545 −0.094 0.842 −0.395 0.380
SCA31 2 ---- ---- ---- ---- ---- ---- ---- ----
SCA6 13 –0.571* 0.042 −0.251 0.409 –0.580* 0.038 −0.311 0.301
SCAx 6 –0.943* 0.005 0.029 0.957 –0.943* 0.005 0.371 0.468
CCA all patients 18 0.155 0.539 0.023 0.928 −0.073 0.772 −0.050 0.843
MSA all patients 34 –0.593* 0.001 −0.367* 0.033 –0.598* 0.001 –0.463* 0.006
  1. Values of correlation coefficient are Spearman’s rho
  2. SCA indicates spinocerebellar ataxia, SCAx the type of SCA was unknown, CCA cortical cerebellar atrophy, MSA multiple system atrophy
  3. p < 0.05