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Table 1 Patient characteristics and annual atrophy changes in the corpus callosum and cerebellum

From: Stratification of disease progression in a broad spectrum of degenerative cerebellar ataxias with a clustering method using MRI-based atrophy rates of brain structures

  Total
(n = 48)
SCA
(n = 21)
MSA-C
(n = 17)
CCA
(n = 10)
p value
Age at onset (years) 52.6 ± 12.5 46.2 ± 13.1* 57.5 ± 10.0 57.6 ± 9.2 0.005
Age at study entry (years) 60.5 ± 11.3 56.6 ± 12.5* 61.4 ± 9.4 67.1 ± 9.0 0.046
Male (%) 50% 62% 47% 30% 0.241
Body height (cm) 159.3 ± 9.0 160.3 ± 9.2 163.0 ± 8.0 154.7 ± 8.2 0.124
AP diameter of the cranium (mm) 181.4 ± 8.6 180.6 ± 8.4 185.0 ± 6.3 177.2 ± 10.7 0.061
Follow-up period (years) 3.1 ± 1.6 3.1 ± 1.7 2.7 ± 1.1 3.6 ± 1.8 0.522
Follow-up period (min-max) (1.25–7.58) (1.50–7.58) (1.25–4.67) (1.25–6.00)  
Number of follow-up studies, median (min-max) 3 (2–6) 3 (2–6) 3 (2–6) 4 (2–6) 0.083
Interval between onset and the first evaluation (years) 8.0 ± 6.4 10.4 ± 7.3 4.0 ± 3.3* 9.4 ± 5.3 0.004
Interval between the first and last evaluation (years) 2.6 ± 1.5 2.6 ± 1.6 2.2 ± 1.3 3.1 ± 1.6 0.308
ICARS score at the first visit 35.5 ± 16.5 36.7 ± 12.9 35.8 ± 23.0 33.2 ± 14.0 0.871
Initial corpus callosum area (mm2) 598.2 ± 79.2 575.2 ± 80.6 657.9 ± 84.9 587.0 ± 47.8 0.042
Initial corpus callosum area index (Adx) 3.38 ± 0.45 3.33 ± 0.50 3.46 ± 0.47 3.32 ± 0.26 0.622
Annual atrophy area in Adx −0.11 ± 0.08 −0.09 ± 0.07 −0.15 ± 0.10 −0.08 ± 0.05 0.026
Initial cerebellar volume (cm3) 84.9 ± 13.7 88.1 ± 12.7 85.5 ± 8.8 78.4 ± 17.9 0.276
Initial cerebellar volume index (Vdx) 0.47 ± 0.09 0.48 ± 0.08 0.45 ± 0.09 0.47 ± 0.11 0.725
Annual atrophy volume in Vdx −0.04 ± 0.02 −0.02 ± 0.02 −0.04 ± 0.02 −0.01 ± 0.03 0.019
Annual increase in ICARS score 4.4 ± 4.5 3.5 ± 2.9 9.8 ± 6.1* 2.9 ± 2.8 0.021
  1. *p < 0.05 vs. the other two subtypes (post-hoc analysis), p < 0.05 vs. CCA (post-hoc analysis)