Table 3 Representative autoantibodies to cerebellar antigens in paraneoplastic cerebellar degenerations

Anti-Yo

53%, breast, uterus, ovaries

Mainly Purkinje cells and few other neurons in the molecular layer

Anti-Hu

15%, SCLC

All neuronal nuclei and cytoplasm

Anti-Tr

5%, Hodgkin’s disease

Purkinje cells cytoplasm and dendrites,

Anti-CV2

4%, SCLC, thymoma

Oligodendrocytes

Anti-Ri

2%, Breast

All neuronal nuclei

Anti-Ma2

2%, Testes, Lung

Nucleoli

Anti-VGCC(P/Q type)

2%, SCLC

Purkinje cells, cytoplasm, dendrites and dot-staining of the molecular layer