From: Cerebellar ataxia with sensory ganglionopathy; does autoimmunity have a role to play?
Gender | Age at 1st presentation | First symptoms | Age at first symptoms | First diagnosis | Second symptoms | Age at second diagnosis | MRI | Abnormal MRS | SNAPs | Gluten serology | Duodenum biopsy | HLA | Other evidence of autoimmunity | Cancer | Age at cancer diagnosis | Genetics | Truly idiopathic |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Female | 48 | Unsteadiness in the dark | 48 | SG | Worsening of balance | 63 | Normal for age | Vermis and hemisphere | Absent | Negative | N/A | DQ2 | ENA+ ANA+, Crohn’s | Negative | |||
Female | 59 | Patchy numbness | 57 | SG | No new symptoms | 60 | Normal for age | Vermis | Asymmetrical | Positive | CD | DQ2 | TPO+, dsDNA+, RF+ | Ovarian | 38 | ||
Male | 40 | Patchy numbness | 38 | SG | Worsening of balance | 62 | Normal for age | Vermis | Absent | Positive | Normal | DQ2 | P-ANCA+, ANA+, GM1+, Sarcoidosis | ||||
Male | 60 | Patchy burning pain | 59 | SG | No new symptoms | 65 | Normal for age | Hemisphere | Asymmetrical | Positive | Normal | DQ2 | |||||
Female | 76 | Unsteadiness/Numbness | 76 | SG | Worsening of balance | 84 | Normal for age | Hemisphere | Asymmetrical | Positive | CD | DQ2 | |||||
Male | 49 | Patchy numbness | 49 | SG | No new symptoms | 72 | Normal for age | Hemisphere | Absent | Negative | N/A | DQ1 | ANA+, RF+ | Negative | |||
Male | 52 | Pain in feet | 49 | SG | Worsening of balance | 70 | Normal for age | Vermis | Asymmetrical | Negative | N/A | DQ1 | ANA+, P-ANCA+, SACE+ | ||||
Female | 55 | Patchy numbness | 55 | SG | Worsening of balance | 69 | Normal for age | Vermis | Asymmetrical | Negative | N/A | Not done | ANA+, ENA+ (Sjogren’s) | ||||
Male | 67 | Unsteadiness | 64 | SG | Worsening of balance | 68 | Cerebellar atrophy | Vermis | Absent | Negative | N/A | DQ2 | ANA+, P-ANCA+, MGUS | ||||
Female | 61 | Patchy pain | 61 | SG | Worsening of balance | 67 | Normal for age | Hemisphere | Asymmetrical | Negative | N/A | Not done | ANA+, ENA+ (Sjogren’s) | ||||
Female | 58 | Patchy numbness | 57 | SG | Worsening of balance | 74 | Normal for age | Hemisphere | Asymmetrical | Negative | N/A | Other | Yes | ||||
Female | 35 | Patchy numbness | 35 | SG | Worsening of balance | 49 | Normal for age | Vermis and hemisphere | Asymmetrical | Negative | N/A | Not done | ANA+, ENA+ (Sjogren’s) | ||||
Female | 42 | Unsteadiness | 42 | Cerebellar ataxia | Patchy sensory loss | 46 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrical | Negative | N/A | DQ1 | Anti-Yo+ | Ovarian | 41 | ||
Male | 14 | Unsteadiness | 14 | Cerebellar ataxia | Worsening of balance | 58 | Cerebellar atrophy | Vermis | Asymmetrical | Positive | CD | DQ2 | GAD+ | Mitochondrial | |||
Female | 57 | Unsteadiness/Dizziness | 55 | Cerebellar ataxia | Sensory symptoms | 69 | Cerebellar atrophy | Vermis | Absent | Positive | Normal | DQ1 | GAD+ | SCA18 | |||
Male | 52 | Unsteadiness | 51 | Cerebellar ataxia | Sensory symptoms | 57 | Cerebellar atrophy | Vermis and hemisphere | Absent | Positive | Normal | DQ8 | Negative | ||||
Female | 50 | Unsteadiness/ Slurred speech | 47 | Cerebellar ataxia | Sensory symptoms | 54 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrical | Positive | Not done | DQ2 | RF+ | Negative | |||
Male | 44 | Unsteadiness | 39 | Cerebellar ataxia | No new symptoms | 46 | Cerebellar atrophy | Vermis | Asymmetrical | Positive | Normal | DQ8 | Negative | ||||
Female | 54 | Unsteadiness | 53 | Cerebellar ataxia | Sensory symptoms | 60 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrica | Positive | Normal | DQ2 | Colon | 69 | Negative | ||
Male | 67 | Unsteadiness | 54 | Cerebellar ataxia | No new symptoms | 76 | Cerebellar atrophy | Vermis and hemisphere | Absent | Positive | Normal | DQ2 | ANA+ | Negative | |||
Male | 66 | Unsteadiness | 66 | Cerebellar ataxia | No new symptoms | 67 | Cerebellar atrophy | Vermis and hemisphere | Absent | Negative | N/A | DQ2 | ANA+ | Bowel | 68 | ||
Female | 66 | Unsteadiness | 63 | Cerebellar ataxia | Sensory symptoms | 68 | Normal for age | Vermis and hemisphere | Absent | Negative | N/A | DQ2 | Negative | Yes | |||
Female | 65 | Unsteadiness | 59 | Cerebellar ataxia | Patch sensory loss | 68 | Cerebellar atrophy | Vermis | Absent | Negative | N/A | DQ8 | C-ANCA+, MGUS | Myltiple myeloma - light chain | 70 | Negative | |
Female | 46 | Unsteadiness | 46 | Cerebellar ataxia | Patchy sensory loss | 58 | Cerebellar atrophy | Vermis | Asymmetrical | Negative | N/A | DQ1 | TPO+ | Negative | |||
Female | 66 | Unsteadiness | 64 | Cerebellar ataxia | No new symptoms | 69 | Normal for age | Vermis and hemisphere | Asymmetrical | Negative | N/A | DQ2 | Negative | Yes | |||
Female | 68 | Unsteadiness | 67 | Cerebellar ataxia | Sensory symptoms | 69 | Normal for age | Vermis and hemisphere | Absent | Negative | N/A | DQ2 | ANA+, TPO+ | ||||
Male | 81 | Unsteadiness | 79 | Cerebellar ataxia | Worsening of balance | 85 | Normal for age | Vermis and hemisphere | Asymmetrical | Negative | N/A | Not done | MGUS | Melanoma/ Possibly prostate | 86 | ||
Female | 29 | Unsteadiness | 8 | Cerebellar ataxia | Sensory symptoms | 33 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrical | Positive | Normal | DQ2 | OCB+, TPO+, GAD+ (one occasion only) | Negative | |||
Male | 43 | Unsteadiness | 34 | Both at the same time | 43 | Cerebellar atrophy | Hemisphere | Asymmetrical | Positive | Normal | DQ2 | RF+ | |||||
Female | 61 | Unsteadiness/Numbness | 60 | Both at the same time | 61 | Cerebellar atrophy | Vermis | Absent | Positive | Normal | DQ1 | Malignancy of unknown primary location | 64 | Negative | |||
Female | 81 | Unsteadiness | 80 | Both at the same time | 81 | Cerebellar atrophy | Vermis | Asymmetrical | Positive | Normal | Not done | ||||||
Male | 51 | Unsteadiness/Numbness | 51 | Both at the same time | 51 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrical | Positive | Normal | DQ1 | ||||||
Female | 55 | Unsteadiness/Pain | 49 | Both at the same time | 55 | Cerebellar atrophy | Vermis | Absent | Negative | N/A | DQ1 | GAD+, P-ANCA+ | Uterus | 39 | Negative | ||
Male | 64 | Unsteadiness | 54 | Both at the same time | 64 | Cerebellar atrophy | Vermis and hemisphere | Absent | Negative | N/A | DQ8 | MGUS | Negative | ||||
Male | 70 | Unsteadiness | 67 | Both at the same time | 70 | Normal for age | Vermis | Absent | Negative | N/A | DQ1 | C-ANCA+ | |||||
Male | 54 | Unsteadiness | 49 | Both at the same time | 54 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrical | Negative | N/A | DQ2 | TPO+ | |||||
Female | 70 | Unsteadiness | 69 | Both at the same time | 70 | Normal for age | Vermis and hemisphere | Asymmetrical | Negative | N/A | Not done | ANA+, ENA+ (Sjogren’s), RF+ | Bowel | 71 | |||
Male | 57 | Unsteadiness | 55 | Both at the same time | 57 | Cerebellar atrophy | Vermis | Absent | Positive | Normal | DQ2 | Negative | |||||
Male | 61 | Unsteadiness/Numbness | 61 | Both at the same time | 62 | Normal for age | Vermis and hemisphere | Asymmetrical | Positive | Normal | DQ8 | ENA+ | |||||
Female | 69 | Unsteadiness | 64 | Both at the same time | 69 | Cerebellar atrophy | Vermis and hemisphere | Asymmetrical | Positive | Normal | DQ8 | P-ANCA+ |