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Table 1 Postmortem cerebellar changes in our patient

From: Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor

Measure Data from current casea Contextual comments (i.e., published comparative data)
Cerebellar Cortex
 Torpedoes (LH&E) 17 In a prior publication [16], the mean value in ET cases = 10.5 ± 8.0 and in controls = 1.7 ± 1.4. None of the 21 controls had a value >5.
 Torpedoes (Bielschowsky) 19 In a prior publication [16], the mean value in ET cases = 16.5 ± 14.2 and in controls = 3.3 ± 7.3.
 Axonal changes (calbindinD28k)   In a prior publication [14]:
  Thickened axonal profiles 1.2 (0.8) 0.6 ± 0.7 (cases) vs. 0.4 ± 0.6 (controls)
  Axonal branching 10.8 (7.5) 0.3 ± 0.4 (cases) vs. 0.1 ± 0.2 (controls)
  Axonal recurrent collaterals 16.8 (11.7) 1.0 ± 0.8 (cases) vs. 0.4 ± 0.5 (controls)
  Arciform axons 0.10 (0.07) 0.08 ± 0.11 (cases) vs. 0.04 ± 0.07 (controls)
  Terminal axonal sprouting 0.13 (0.09) 0.19 ± 0.22 (cases) vs. 0.07 ± 0.14 (controls)
 Dendritic swellings (LH&E) 3 In a prior publication [44], the mean value in 20 ET cases = 1.50 ± 1.79 and in 19 controls = 0.05 ± 0.23. None of the 19 controls had >1 dendritic swelling.
 Dendritic swellings (Bielschowsky) 3.5 In a prior publication [44], the mean value in 20 ET cases = 2.70 ± 3.10 and in 19 controls = 0.37 ± 0.50. None of the 19 controls had >1 dendritic swelling.
 Purkinje cell count (LH&E, 15 100× fields) 0.8 In a prior publication [16], the mean value in ET cases = 7.2 ± 2.6 and in controls = 9.6 ± 3.4. None of the 33 ET cases or 21 controls had values as low as 0.8.
 Heterotopic Purkinje cells (LH&E) 1.5 In a prior publication [46], the median number in 35 ET cases = 3 and in 32 controls = 1.
 Basket rating (Bielschowsky) 3 In a prior publication [17], 8/37 (21.6%) ET cases and 3/69 (4.3%) controls had this value.
ION
 ION neuronal linear density (LH&E), neurons/μm × 1000 2.3 In a prior publication [23], the mean value in 14 ET cases = 9.4 ± 3.2 and in 15 controls = 8.8 ± 3.1.
Dentate Nucleus
 Dentate dorsal neuronal density,  LH&E), neurons/μm2 × 10−5 1.95 In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.5 and in 25 controls = 1.5 ± 0.4.
 Dentate ventral neuronal density  (LH&E), neurons/μm2 × 10−5 1.7 In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.5 and in 25 controls = 1.4 ± 0.5.
 Dentate total neuronal density, (LH&E), neurons/μm2 × 10−5 1.8 In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.4 and in 25 controls = 1.4 ± 0.5.
  1. ET Essential tremor, ION Inferior olivary nucleus, LH&E Luxol fast blue counterstained with hematoxylin-eosin
  2. aValues are mean (median)