From: Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor

Measure |
Data from current case^{a}
| Contextual comments (i.e., published comparative data) |
---|---|---|

Cerebellar Cortex | ||

Torpedoes (LH&E) | 17 | In a prior publication [16], the mean value in ET cases = 10.5 ± 8.0 and in controls = 1.7 ± 1.4. None of the 21 controls had a value >5. |

Torpedoes (Bielschowsky) | 19 | In a prior publication [16], the mean value in ET cases = 16.5 ± 14.2 and in controls = 3.3 ± 7.3. |

Axonal changes (calbindin_{D28k})
| In a prior publication [14]: | |

Thickened axonal profiles | 1.2 (0.8) | 0.6 ± 0.7 (cases) vs. 0.4 ± 0.6 (controls) |

Axonal branching | 10.8 (7.5) | 0.3 ± 0.4 (cases) vs. 0.1 ± 0.2 (controls) |

Axonal recurrent collaterals | 16.8 (11.7) | 1.0 ± 0.8 (cases) vs. 0.4 ± 0.5 (controls) |

Arciform axons | 0.10 (0.07) | 0.08 ± 0.11 (cases) vs. 0.04 ± 0.07 (controls) |

Terminal axonal sprouting | 0.13 (0.09) | 0.19 ± 0.22 (cases) vs. 0.07 ± 0.14 (controls) |

Dendritic swellings (LH&E) | 3 | In a prior publication [44], the mean value in 20 ET cases = 1.50 ± 1.79 and in 19 controls = 0.05 ± 0.23. None of the 19 controls had >1 dendritic swelling. |

Dendritic swellings (Bielschowsky) | 3.5 | In a prior publication [44], the mean value in 20 ET cases = 2.70 ± 3.10 and in 19 controls = 0.37 ± 0.50. None of the 19 controls had >1 dendritic swelling. |

Purkinje cell count (LH&E, 15 100× fields) | 0.8 | In a prior publication [16], the mean value in ET cases = 7.2 ± 2.6 and in controls = 9.6 ± 3.4. None of the 33 ET cases or 21 controls had values as low as 0.8. |

Heterotopic Purkinje cells (LH&E) | 1.5 | In a prior publication [46], the median number in 35 ET cases = 3 and in 32 controls = 1. |

Basket rating (Bielschowsky) | 3 | In a prior publication [17], 8/37 (21.6%) ET cases and 3/69 (4.3%) controls had this value. |

ION | ||

ION neuronal linear density (LH&E), neurons/μm × 1000 | 2.3 | In a prior publication [23], the mean value in 14 ET cases = 9.4 ± 3.2 and in 15 controls = 8.8 ± 3.1. |

Dentate Nucleus | ||

Dentate dorsal neuronal density,
LH&E), neurons/μm^{2} × 10^{−5}
| 1.95 | In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.5 and in 25 controls = 1.5 ± 0.4. |

Dentate ventral neuronal density
(LH&E), neurons/μm^{2} × 10^{−5}
| 1.7 | In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.5 and in 25 controls = 1.4 ± 0.5. |

Dentate total neuronal density, (LH&E), neurons/μm^{2} × 10^{−5}
| 1.8 | In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.4 and in 25 controls = 1.4 ± 0.5. |