Table 1 Postmortem cerebellar changes in our patient

 Torpedoes (LH&E)

17

In a prior publication [16], the mean value in ET cases = 10.5 ± 8.0 and in controls = 1.7 ± 1.4. None of the 21 controls had a value >5.

 Torpedoes (Bielschowsky)

19

In a prior publication [16], the mean value in ET cases = 16.5 ± 14.2 and in controls = 3.3 ± 7.3.

 Axonal changes (calbindin_D28k)

In a prior publication [14]:

  Thickened axonal profiles

1.2 (0.8)

0.6 ± 0.7 (cases) vs. 0.4 ± 0.6 (controls)

  Axonal branching

10.8 (7.5)

0.3 ± 0.4 (cases) vs. 0.1 ± 0.2 (controls)

  Axonal recurrent collaterals

16.8 (11.7)

1.0 ± 0.8 (cases) vs. 0.4 ± 0.5 (controls)

  Arciform axons

0.10 (0.07)

0.08 ± 0.11 (cases) vs. 0.04 ± 0.07 (controls)

  Terminal axonal sprouting

0.13 (0.09)

0.19 ± 0.22 (cases) vs. 0.07 ± 0.14 (controls)

 Dendritic swellings (LH&E)

3

In a prior publication [44], the mean value in 20 ET cases = 1.50 ± 1.79 and in 19 controls = 0.05 ± 0.23. None of the 19 controls had >1 dendritic swelling.

 Dendritic swellings (Bielschowsky)

3.5

In a prior publication [44], the mean value in 20 ET cases = 2.70 ± 3.10 and in 19 controls = 0.37 ± 0.50. None of the 19 controls had >1 dendritic swelling.

 Purkinje cell count (LH&E, 15 100× fields)

0.8

In a prior publication [16], the mean value in ET cases = 7.2 ± 2.6 and in controls = 9.6 ± 3.4. None of the 33 ET cases or 21 controls had values as low as 0.8.

 Heterotopic Purkinje cells (LH&E)

1.5

In a prior publication [46], the median number in 35 ET cases = 3 and in 32 controls = 1.

 Basket rating (Bielschowsky)

3

In a prior publication [17], 8/37 (21.6%) ET cases and 3/69 (4.3%) controls had this value.

 ION neuronal linear density (LH&E), neurons/μm × 1000

2.3

In a prior publication [23], the mean value in 14 ET cases = 9.4 ± 3.2 and in 15 controls = 8.8 ± 3.1.

 Dentate dorsal neuronal density,

 LH&E), neurons/μm² × 10⁻⁵ 

1.95

In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.5 and in 25 controls = 1.5 ± 0.4.

 Dentate ventral neuronal density

 (LH&E), neurons/μm² × 10⁻⁵

1.7

In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.5 and in 25 controls = 1.4 ± 0.5.

 Dentate total neuronal density, (LH&E), neurons/μm² × 10⁻⁵

1.8

In a prior publication [55], the mean value in 25 ET cases = 1.5 ± 0.4 and in 25 controls = 1.4 ± 0.5.