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Table 2 The mean and median number (No.) of focal abnormal signal intensities (FASI) in different brain locations on the first and last MRI in patients with repeat MRI

From: Cerebellar radiological abnormalities in children with neurofibromatosis type 1: part 2 - a neuroimaging natural history study with clinical correlations

Brain location

No. of patients at baseline

No. of FASI on first MRI

No. of patients at last MRI

No. of FASI on last MRI

*p-value

Mean (SD)

Median (min.-max.)

Mean (SD)

Median (min.-max.)

Overall

35

7.3 (3.5)

7 (2–17)

35

4.8 (3.8)

5 (0–15)

<  0.0001

Infratentorial

36

3.5 (2)

3 (0–10)

36

2.1 (2.3)

1.5 (0–10)

0.0002

Supratentorial

35

3.8 (2.2)

4 (0–8)

35

2.7 (2)

3 (0–7)

0.001

Cerebellum

36

2.8 (1.6)

2.5 (0–9)

36

1.7 (1.9)

1 (0–9)

<  0.0001

Brainstem

36

1.9 (1.5)

2 (0–5)

36

1.3 (1.4)

1 (0–4)

0.007

Thalamus/hypothalamus

36

0.5 (0.8)

0 (0–2)

36

0.3 (0.6)

0 (0–2)

0.031

Basal ganglia/internal capsule

36

1.3 (1.1)

1 (0–4)

36

1 (1)

1 (0–3)

0.106

Cerebrum

35

0.7 (1)

0 (0–3)

35

0.7 (1.2)

0 (0–4)

0.812

  1. *Significance level on paired t-test is the difference in the mean number of FASI between the first and last MRI in patients who had a repeat MRI, min.: minimum, max.: maximum