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Table 2 The mean and median number (No.) of focal abnormal signal intensities (FASI) in different brain locations on the first and last MRI in patients with repeat MRI

From: Cerebellar radiological abnormalities in children with neurofibromatosis type 1: part 2 - a neuroimaging natural history study with clinical correlations

Brain location No. of patients at baseline No. of FASI on first MRI No. of patients at last MRI No. of FASI on last MRI *p-value
Mean (SD) Median (min.-max.) Mean (SD) Median (min.-max.)
Overall 35 7.3 (3.5) 7 (2–17) 35 4.8 (3.8) 5 (0–15) <  0.0001
Infratentorial 36 3.5 (2) 3 (0–10) 36 2.1 (2.3) 1.5 (0–10) 0.0002
Supratentorial 35 3.8 (2.2) 4 (0–8) 35 2.7 (2) 3 (0–7) 0.001
Cerebellum 36 2.8 (1.6) 2.5 (0–9) 36 1.7 (1.9) 1 (0–9) <  0.0001
Brainstem 36 1.9 (1.5) 2 (0–5) 36 1.3 (1.4) 1 (0–4) 0.007
Thalamus/hypothalamus 36 0.5 (0.8) 0 (0–2) 36 0.3 (0.6) 0 (0–2) 0.031
Basal ganglia/internal capsule 36 1.3 (1.1) 1 (0–4) 36 1 (1) 1 (0–3) 0.106
Cerebrum 35 0.7 (1) 0 (0–3) 35 0.7 (1.2) 0 (0–4) 0.812
  1. *Significance level on paired t-test is the difference in the mean number of FASI between the first and last MRI in patients who had a repeat MRI, min.: minimum, max.: maximum