Cerebellar radiological abnormalities in children with neurofibromatosis type 1: part 2 - a neuroimaging natural history study with clinical correlations

Table 3 The effect of increasing age on the number of focal abnormal signal intensities (FASI) in different brain locations in patients with NF1

Brain location	Estimate of age effect of FASI number	^aDF (numerator, denominator)	F-value	P-value
^bOverall	−0.05503	1166	44.99	< 0.0001
Infratentorial	− 0.06517	1,35	18.78	0.0001
Supratentorial	−0.03646	1,34	7.27	0.011
Cerebellum	−0.06929	1,35	18.38	0.0001
Brainstem	−0.05143	1,35	6.49	0.015
Thalamus/ hypothalamus	−0.1023	1,35	6.51	0.015
Basal ganglia/internal capsule	−0.04034	1,35	4.23	0.047
Cerebrum	0.02318	1,34	0.67	0.418

^aDF: degrees of freedom
^bData from all MRI repeats in each patient were used for this analysis. For more specific brain locations (below), data from the first and last MRI were used