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Table 1 Nonmotor symptoms in spinocerebellar ataxiasa

From: Nonmotor symptoms in spinocerebellar ataxias (SCAs)

 

SCA1

SCA2

SCA3

SCA6

SCA7

SCA10

Fatigue [12,13,14,15]

 Severity

+++

++

+

 Prevalence

NA

NA

36%

21%

NA

24%

Pain [15,16,17]

 Severity

NA

NA

++

NA

NA

 Prevalence

NA

NA

36–47%

NA

NA

18%

Dysautonomia [15, 18,19,20,21,22,23,24,25]

 Severity

++

++

++

NA

 Prevalence

67–70%b

20–95%b

22–100%b

0%

NA

1–8%

RBD [15, 26, 27]

 Severity

NA

++

NA

+

 Prevalence

NA

NA

43–55%

NA

NA

10–20%

Depression [15, 28,29,30,31,32,33]

 Severity

+

+

+/2

+/2

NA

+

 Prevalence

25–50%

23–33%

13–60%

27–75%

NA

62%

Cognition [15, 34,35,36,37,38,39,40,41,42,43,44,45,46]

 Severity

+

+/2

+/2

+

+/3

+

 Prevalence

50%

25%

33%

45%

50%

33%

Hyposmia [47,48,49,50,51,52]

 Severity

NA

++

NA

+/2

 Prevalence

NA

50%

NA

NA

33%

NA

  1. RBD: REM sleep behavior disorder; + present (severity rated as ½ very mild, 1:mild, 2: moderate, 3: severe); − no different from controls or not detected; NA: not available
  2. aTable made from comparison of data found in the cited references
  3. bHigh prevalence of asymptomatic cardiac dysatonomia