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Table 1 Nonmotor symptoms in spinocerebellar ataxiasa

From: Nonmotor symptoms in spinocerebellar ataxias (SCAs)

  SCA1 SCA2 SCA3 SCA6 SCA7 SCA10
Fatigue [12,13,14,15]
 Severity +++ ++ +
 Prevalence NA NA 36% 21% NA 24%
Pain [15,16,17]
 Severity NA NA ++ NA NA
 Prevalence NA NA 36–47% NA NA 18%
Dysautonomia [15, 18,19,20,21,22,23,24,25]
 Severity ++ ++ ++ NA
 Prevalence 67–70%b 20–95%b 22–100%b 0% NA 1–8%
RBD [15, 26, 27]
 Severity NA ++ NA +
 Prevalence NA NA 43–55% NA NA 10–20%
Depression [15, 28,29,30,31,32,33]
 Severity + + +/2 +/2 NA +
 Prevalence 25–50% 23–33% 13–60% 27–75% NA 62%
Cognition [15, 34,35,36,37,38,39,40,41,42,43,44,45,46]
 Severity + +/2 +/2 + +/3 +
 Prevalence 50% 25% 33% 45% 50% 33%
Hyposmia [47,48,49,50,51,52]
 Severity NA ++ NA +/2
 Prevalence NA 50% NA NA 33% NA
  1. RBD: REM sleep behavior disorder; + present (severity rated as ½ very mild, 1:mild, 2: moderate, 3: severe); − no different from controls or not detected; NA: not available
  2. aTable made from comparison of data found in the cited references
  3. bHigh prevalence of asymptomatic cardiac dysatonomia