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Table 1 Summary of neuropsychological assessment data by subtype of SCA

From: Comparison of cognitive profiles in spinocerebellar ataxia subtypes: a case series

 

Case 1

Case 2

Case 3

Case 4

SCA Subtype

  

2

3

6

14

Age (years)

66

53

70

46

Disease Duration (years)

40

12

25

3

SARA Score

9

21

18.5

11

Global

MMSE [4]

–

–

–

–

Verbal Memory

Verbal List (RBANS or CVLT-II) [5, 6]

Immediate Recall

+++

+

++

–

 

Delayed Recall

++

–

++

–

 

Recognition

+++

–

–

+

Verbal Story (RBANS or WMS-IV) [5, 7]

Immediate Recall

++

–

–

–

 

Delayed Recall

++

–

–

–

 

Recognition

+++

–

–

–

Visual Memory

Simple (BVMT-R) [8]

Immediate Recall

–

++

+

++

 

Delayed Recall

–

++

–

++

 

Recognition

–

–

+

+

Complex (RCFT) [9]

Immediate Recall

/

–

/

++

 

Delayed Recall

/

–

/

++

 

Recognition

/

–

/

++

Visuospatial

Line Orientation (RBANS or JLO) [5, 10]

 

–

–

–

–

 

Clock Copy [11]

 

–

+

–

–

Language

Boston Naming Test [12]

 

–

–

–

–

Verbal Fluency [13]

Phonemic

–

+++

–

++

 

Semantic

+

++

++

–

Executive Functions

Attention and Processing Speed

WCST [14]

Errors

–

–

–

+

 

Perseverative Responses

+

+

–

–

 

Categories Completed

+

–

+

+

Trail Making Test Part B [15]

 

++

++

+

+

Trail Making Test Part A [15]

 

++

+

+

+

Symbol-Digit Coding (RBANS or SDMT) [5, 16]

 

+

++

+

+

Depression

Screening Measure (BDI-II or GDS) [17, 18]

 

+

++

–

–

  1. + = Mildly Impaired, ++ = Moderately Impaired, +++ = Severely Impaired, − = Within Normal Limits, / = Not assessed. All comparisons are with normative data. SCA2 = spinocerebellar ataxia type 2, SCA3 = spinocerebellar ataxia type 3, SCA6 = spinocerebellar ataxia type 6, SCA14 = spinocerebellar ataxia type 14. MMSE = Mini Mental State Examination; RBANS = Repeatable Battery for the Assessment of Neuropsychological Status; CVLT-II = California Verbal Learning Test – Second Edition; WMS-IV = Wechsler Memory Scale – Fourth Edition; BVMT-R = Brief Visuospatial Memory Test – Revised; RCFT = Rey Complex Figure Test; JLO = Judgement of Line Orientation; WCST = Wisconsin Card Sorting Test; SDMT = Symbol Digit Modalities Test; BDI-II = Beck Depression Inventory – Second Edition; GDS = Geriatric Depression Scale