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Table 2 Clinical characteristics in subjects with normal and abnormal auditory, vestibular and oculomotor measures. Statistical comparisons were done using U Mann-Whitney test. Median, Q25 and Q75 for all subgroups. Results in bold are significant

From: Vestibular impact of Friedreich ataxia in early onset patients

  Age at disease onset (years) Age at visit (years) Disease duration (months) ICARS (total score) FARS (total score) SARA (total score) Shorter GAA repeat length
ABR Normal (n = 19/39) 11.96 (7.26–13.64) P = 0.13 16.39 (13.17–21.18) P = 0.5 56.8 (39.6–119.0) P = 0.004 29 (19–39.5) P = 0.0003 57.75 (50.5–74.5) P = 0.0001 12 (9–16.38) P = 0.0002 700 (600–766) P = 0.05
Abnormal (n = 20/39) 9.43 (5.94–10.29) 17.72 (15–20.69) 103.2 (81.6–126.9) 38,5 (33.5–45.3) 74 (68.6–81.5) 16.25 (13.5–18.63) 733 (600–875.25)
Caloric Normal (n = 33/40) 9.57 (6.16–13.43) P = 0.644 16.41 (13.75–20.48) P = 0.835 80.62 (51.24–114.12) P = 0.147 32.0 (24–43) P = 0.332 65 (55–76.5) P = 0.182 13.5 (10.5–17.75) P = 0.458 700 (600–833) P = 0.172
Abnormal (n = 7/40) 9.67 (7.92–10.30) 17.91 (12.7–21.06) 122.17 (99.12–136.81) 38.5 (30.5–44.25) 76.25 (70.25–83) 14.25 (11.88–21.88) 783 (766–867)
HIT Normal (n = 19/42) 10.06 (5.02–13.58) P = 0.813 16.39 (12.03–18.51) P = 0.159 70.97 (46.18–94.13) P = 0.009 26 (19–31.5) P = 0.0004 57.5 (48.63–70.38) P = 0.005 11 (9.5–13.25) P = 0.0002 733 (600–858) P = 0.703
Abnormal (n = 23/42) 9.76 (7.76–12) 17.53 (15.38–21.04) 114.12 (74.97–138.65) 42 (34.75–45.25) 76 (66.75–82.5) 16.75 (14.88–19.63) 700 (600–783.75)
Gaze Stability Stable (n = 11/42) 13.13 (6.39–14.52) P = 0.177 15.5 (11.79–19.69) P = 0.417 51.3 (44.58–80.62) P = 0.007 25.5 (18–35.75) P = 0.026 54.25 (43.37–54.25) P = 0.014 10.5 (9–15.63) P = 0.014 611.5 (540–733) P = 0.163
Unstable (n = 31/42) 9.42 (6.66–12.09) 16.82 (14.78–20.69) 98.7 (62.37–129.56) 35.5 (29.5–43) 70.75 (61.62–78.87) 15.25 (13–18.5) 733 (600–850)
Ocular Saccades Normal (n = 10/42) 12.38 (7.99–13.45) P = 0.180 16.83 (13.17–20.62) P = 0.873 56.84 (47.77–92.78) P = 0.114 55 (48–59) P = 0.142 26 (23–41) P = 0.026 11.5 (8.5–16) P = 0.16 700 (600–800) P = 0.536
Dysmetric (n = 32/42) 9.76 (5.23–12.14) 16.62 (13.68–20.69) 94.13 (59.51–126.91) 70.25 (61.63–78.88) 35 (29–43) 14.75 (11.63–18.25) 716.5 (600–833)