Table 2 Clinical characteristics in subjects with normal and abnormal auditory, vestibular and oculomotor measures. Statistical comparisons were done using U Mann-Whitney test. Median, Q25 and Q75 for all subgroups. Results in bold are significant
From: Vestibular impact of Friedreich ataxia in early onset patients
| Â | Age at disease onset (years) | Age at visit (years) | Disease duration (months) | ICARS (total score) | FARS (total score) | SARA (total score) | Shorter GAA repeat length | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ABR | Normal (n = 19/39) | 11.96 (7.26–13.64) | P = 0.13 | 16.39 (13.17–21.18) | P = 0.5 | 56.8 (39.6–119.0) | P = 0.004 | 29 (19–39.5) | P = 0.0003 | 57.75 (50.5–74.5) | P = 0.0001 | 12 (9–16.38) | P = 0.0002 | 700 (600–766) | P = 0.05 |
Abnormal (n = 20/39) | 9.43 (5.94–10.29) | 17.72 (15–20.69) | 103.2 (81.6–126.9) | 38,5 (33.5–45.3) | 74 (68.6–81.5) | 16.25 (13.5–18.63) | 733 (600–875.25) | ||||||||
Caloric | Normal (n = 33/40) | 9.57 (6.16–13.43) | P = 0.644 | 16.41 (13.75–20.48) | P = 0.835 | 80.62 (51.24–114.12) | P = 0.147 | 32.0 (24–43) | P = 0.332 | 65 (55–76.5) | P = 0.182 | 13.5 (10.5–17.75) | P = 0.458 | 700 (600–833) | P = 0.172 |
Abnormal (n = 7/40) | 9.67 (7.92–10.30) | 17.91 (12.7–21.06) | 122.17 (99.12–136.81) | 38.5 (30.5–44.25) | 76.25 (70.25–83) | 14.25 (11.88–21.88) | 783 (766–867) | ||||||||
HIT | Normal (n = 19/42) | 10.06 (5.02–13.58) | P = 0.813 | 16.39 (12.03–18.51) | P = 0.159 | 70.97 (46.18–94.13) | P = 0.009 | 26 (19–31.5) | P = 0.0004 | 57.5 (48.63–70.38) | P = 0.005 | 11 (9.5–13.25) | P = 0.0002 | 733 (600–858) | P = 0.703 |
Abnormal (n = 23/42) | 9.76 (7.76–12) | 17.53 (15.38–21.04) | 114.12 (74.97–138.65) | 42 (34.75–45.25) | 76 (66.75–82.5) | 16.75 (14.88–19.63) | 700 (600–783.75) | ||||||||
Gaze Stability | Stable (n = 11/42) | 13.13 (6.39–14.52) | P = 0.177 | 15.5 (11.79–19.69) | P = 0.417 | 51.3 (44.58–80.62) | P = 0.007 | 25.5 (18–35.75) | P = 0.026 | 54.25 (43.37–54.25) | P = 0.014 | 10.5 (9–15.63) | P = 0.014 | 611.5 (540–733) | P = 0.163 |
Unstable (n = 31/42) | 9.42 (6.66–12.09) | 16.82 (14.78–20.69) | 98.7 (62.37–129.56) | 35.5 (29.5–43) | 70.75 (61.62–78.87) | 15.25 (13–18.5) | 733 (600–850) | ||||||||
Ocular Saccades | Normal (n = 10/42) | 12.38 (7.99–13.45) | P = 0.180 | 16.83 (13.17–20.62) | P = 0.873 | 56.84 (47.77–92.78) | P = 0.114 | 55 (48–59) | P = 0.142 | 26 (23–41) | P = 0.026 | 11.5 (8.5–16) | P = 0.16 | 700 (600–800) | P = 0.536 |
Dysmetric (n = 32/42) | 9.76 (5.23–12.14) | 16.62 (13.68–20.69) | 94.13 (59.51–126.91) | 70.25 (61.63–78.88) | 35 (29–43) | 14.75 (11.63–18.25) | 716.5 (600–833) | ||||||||