Table 1 Experimental animal studies
From: Cerebellum and micturition: what do we know? A systematic review
| Author, year | Aim | Method | Urodynamic | Cerebellum effect |
|---|---|---|---|---|
| Bradley et al. a et b 1969 | Modulation of reflex micturition | Electrostimulation of fastigial nucleus, pelvic and pudendal nerves in decerebrate cats and ablation of the cerebellar anterior lobe | Cystometry during filling phase | Tonic depressant effect on micturition reflex which is organized in the pontine mesencephalic reticular formation. Stimulation of pudendal and pelvic nerves afferents demonstrated a bilateral projection to the anterior and posterior vermis. |
| Lisander et al. 1974 | Modulation of bladder mobility | Electrostimulation of fastigial nucleus in cats and after infusion of guanethidin (sympatholytic drug). | Cystometry during filling phase | Inhibition of the bladder mobility induced by saline filling. Suppression of the efferent parasympathetic discharge by a possibly inhibitory action at the spinal level |
| Martner et al. 1975 | Modulation of reflex micturition | Electrostimulation of fastigial nucleus in cats with bladder outlet occluded | Cystometry during filling phase | Fastigial inhibitory influences on the spinal parasympathetic reflexes controlling bladder |
| Nishizawa et al. 1989 | Modulation of reflex micturition | Cerebellectomy in decerebrate dog | Cystometry and EMG of the urethral sphincter | Inhibitory role in the collecting phase and a facilitator role in the emptying phase. |
| Deruyver et al. 2015 | Micturition cycle and change in brain metabolism | PET study in rats | Cystometry | Hypometabolism in the rigth cerebellum during volume-induced voiding or isovolumetric bladder contraction |