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Table 1 Experimental animal studies

From: Cerebellum and micturition: what do we know? A systematic review

Author, year

Aim

Method

Urodynamic

Cerebellum effect

Bradley et al. a et b 1969

Modulation of reflex micturition

Electrostimulation of fastigial nucleus, pelvic and pudendal nerves in decerebrate cats and ablation of the cerebellar anterior lobe

Cystometry during filling phase

Tonic depressant effect on micturition reflex which is organized in the pontine mesencephalic reticular formation. Stimulation of pudendal and pelvic nerves afferents demonstrated a bilateral projection to the anterior and posterior vermis.

Lisander et al. 1974

Modulation of bladder mobility

Electrostimulation of fastigial nucleus in cats and after infusion of guanethidin (sympatholytic drug).

Cystometry during filling phase

Inhibition of the bladder mobility induced by saline filling. Suppression of the efferent parasympathetic discharge by a possibly inhibitory action at the spinal level

Martner et al. 1975

Modulation of reflex micturition

Electrostimulation of fastigial nucleus in cats with bladder outlet occluded

Cystometry during filling phase

Fastigial inhibitory influences on the spinal parasympathetic reflexes controlling bladder

Nishizawa et al. 1989

Modulation of reflex micturition

Cerebellectomy in decerebrate dog

Cystometry and EMG of the urethral sphincter

Inhibitory role in the collecting phase and a facilitator role in the emptying phase.

Deruyver et al. 2015

Micturition cycle and change in brain metabolism

PET study in rats

Cystometry

Hypometabolism in the rigth cerebellum during volume-induced voiding or isovolumetric bladder contraction