Author/year | Interventions | Relevant statistical data | Grade |
---|---|---|---|
Dongmei et al., 2011 [19] | UCMSCs (1 × 106 /kg; 10 mL) with 5 mg dexamethasone was injected intrathecally weekly for 4 weeks by lumbar punctures, resulting in 4 injections for 4 weeks. | ICARS = ↑ posture, gait disorders, coordination, speech disorders, ocular motility. ADL = ↑ self-care ability. | ⊕ ⊕ ϴϴ Low |
Jin et al., 2013 [20] | UCMSCs (4 × 107) in 30 ml saline solution IV in 30 min and 3 treatments, 2 × 107 in 30 ml IV and 2 × 107 in 1 ml IT simultaneously. 4 applications a week apart. | After the first application of UCMSCs, 38% (6/16) ↑ BBS. From 3 to 6 months 63% (10/16) ↑ BBS and there were statistically significant improvements over the baseline. After 1-year 7/16 (44%) ↑ BBS over the baseline, and only 5/16 (31%) of the patients suffered from the disease. ↑ ICARS in the 3rd and 6th month. | ⊕ ⊕ ϴϴ Low |
Tsai et al., 2017 [21] | 100 g of adipose tissue was collected by liposuction of the abdominal region of two healthy donors. The AD-MSC were frozen at a concentration of 7 × 107 viable cells in 20 ml of cryopreservation solution. On the day of infusion, thawed AD-MSCs were mixed with 100 ml with normal saline and administered IV in 40 min. | SARA score evolution: 13.25 at the baseline, 13.0 in the first 15 days, 12.75 at 6 months, and 13.5 at 12 months. | ⊕ ⊕ ϴϴ Low |