The merit of proton magnetic resonance spectroscopy in the longitudinal assessment of spinocerebellar ataxias and multiple system atrophy-cerebellar type

Table 2 Comparison of ¹ H MRS metabolites between the patients with SCA, MSA-C and controls and between 2 assessments in each group

		Metabolites on		The 1 ^st MRS ^* vs. controls	The 2 ^nd MRS ^* vs. controls	1 ^st vs. 2 ^nd MRS ^#
		the 1 ^st MRS	the 2 ^nd MRS	The 1 ^st MRS ^* vs. controls	The 2 ^nd MRS ^* vs. controls	1 ^st vs. 2 ^nd MRS ^#
Cerebellar hemispheres	NAA/Cr
	SCA2	0.65 ± 0.10	0.72 ± 0.06	0.000	0.000	0.113
	SCA3	0.88 ± 0.10	0.85 ± 0.08	0.000	0.000	0.073
	SCA6	0.83 ± 0.07	0.87 ± 0.08	0.001	0.014	0.440
	MSA-C	0.58 ± 0.14	0.62 ± 0.23	0.000	0.000	0.331
	HC	1.00 ± 0.12	-	-	-	-
	Cho/Cr
	SCA2	0.58 ± 0.07	0.62 ± 0.05	0.001	0.019	0.031
	SCA3	0.68 ± 0.09	0.65 ± 0.08	0.392	0.027	0.098
	SCA6	0.69 ± 0.08	0.65 ± 0.04	0.710	0.279	0.116
	MSA-C	0.50 ± 0.10	0.52 ± 0.14	0.000	0.000	0.955
	HC	0.70 ± 0.09	-	-	-	-
	NAA/Cho
	SCA2	1.14 ± 0.27	1.16 ± 0.16	0.004	0.000	0.796
	SCA3	1.30 ± 0.17	1.31 ± 0.15	0.000	0.001	0.768
	SCA6	1.23 ± 0.15	1.34 ± 0.10	0.008	0.174	0.113
	MSA-C	1.17 ± 0.29	1.21 ± 0.28	0.000	0.000	0.263
	HC	1.45 ± 0.19	-
Vermis	NAA/Cr
	SCA2	0.74 ± 0.05	0.70 ± 0.09	0.000	0.003	0.421
	SCA3	0.82 ± 0.07	0.80 ± 0.08	0.002	0.000	0.205
	SCA6	0.79 ± 0.06	0.76 ± 0.06	0.024	0.043	0.126
	MSA-C	0.63 ± 0.08	0.64 ± 0.08	0.000	0.000	0.966
	HC	0.90 ± 0.11	-	-	-	-
	Cho/Cr
	SCA2	0.61 ± 0.08	0.55 ± 0.06	0.062	0.003	0.233
	SCA3	0.66 ± 0.07	0.65 ± 0. 08	0.433	0.194	0.910
	SCA6	0.70 ± 0.03	0.65 ± 0.06	0.494	0.463	0.451
	MSA-C	0.54 ± 0.06	0.50 ± 0.11	0.000	0.000	0.178
	HC	0.68 ± 0.07	-	-	-	-
	NAA/Cho
	SCA2	1.22 ± 0.19	1.28 ± 0.07	0.174	0.380	0.833
	SCA3	1.25 ± 0.13	1.22 ± 0.13	0.072	0.002	0.170
	SCA6	1.13 ± 0.10	1.17 ± 0.02	0.024	0.065	0.766
	MSA-C	1.16 ± 0.08	1.31 ± 0.24	0.000	0.991	0.083
	HC	1.32 ± 0.18	-

SCA2: Spinocerebellar ataxia type 2; SCA3: Spinocerebellar ataxia type 3; SCA6: Spinocerebellar ataxia type 6; MSA-C: Multiple system atrophy-cerebellar type; HC: Healthy controls.
^*Mann–Whitney test, p value.
^#Pair-t test, p value.

ISSN: 2053-8871