Figure 5
From: Coeliac disease patients do not produce antibodies to a common cerebellar epitope
Cerebellar monkey brain sections were stained with serum from control and CD patients for cross-reacting IgG antibodies. Anti-Hu human auto-immune serum positive control (a) immunostained the nuclei of PCs and granular cells. Anti-Yo (b) auto-immune serum showed slight immunoreactivity to PC cytoplasm in a granular pattern. Most non-CD control serum showed immunoreactivity of PCs and endothelial cells as demonstrated by patients C7 (c) and C8 (d). Control patient C9 (e) differed from the other controls with punctate immunoreactivity to the nucleus of PCs and granule cells. A representative image of CD patient serum with light immunoreactivity of PCs is shown in panel f (CD5). Serum from patient CD10 (g) stained the nucleoli of all cells of the cerebellum including PCs. CD11 patient serum (h) showed basket-like immmunostaining surrounding the PCs. Arrows indicate PCs and asterisk indicates endothelial staining. Scale bar =50 μm.