Table 4 Reported first line immunotherapy for each subtype of immune-mediated cerebellar ataxias

Gluten ataxia

Induction and maintenance therapies: strict gluten-free diet

(In case of no improvement and negative gluten related antibodies, immunosuppressants or IVIg )

Paraneoplastic cerebellar degeneration

Quick removal of neoplasm must be the first objective of treatment

Induction therapy as soon as possible: mPSL, IVIg, immunosuppressants, or/and plasma exchange

Discussion according associated Abs

Maintenance therapy: continuous oral PSL, IVIg, immunosuppressants

Anti-GAD Abs associated cerebellar ataxia

Induction therapy: mPSL, IVIg, immunosuppressants, plasma exchange, or/and rituximab

Maintenance therapy: continuous oral PSL, IVIg, immunosuppressants, or/and rituximab