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Table 3 Patient’s characteristics and measurements of infratentorial structures

From: MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy

  Healthy control subjects All patients    Subtype   
  (n = 30) (n = 86) p valueb SCA (n = 34) CCA (n = 18) MSA (n = 34) p valuec
Age (years) 64.2 ± 18.7 60.5 ± 10.7 0.001 57.0 ± 12.0 65.2 ± 10.7 61.3 ± 8.1 0.027
Male sex 15 (50 %) 48 (55.8 %) 0.526 19 (55.9 %) 7 (38.9 %) 22 (64.7 %) 0.284
Body height (cm) 163.5 ± 6.7 160.4 ± 8.2 0.285 161.1 ± 8.6 156.9 ± 7.9 161.5 ± 7.7 0.124
Body weight (kg) 64.2 ± 18.7 57.3 ± 10.7 0.039 57.1 ± 10.8 57.9 ± 11.7 57.2 ± 10.3 0.959
MRI measurement
 Cranial AP diameter (mm) 181.6 ± 10.8 184.7 ± 9.3 0.074 184.1 ± 9.3 181.2 ± 11.7 187.1 ± 7.2 0.086
 Posterior cranial fossa volume (ml) 274.0 ± 26.7 260.0 ± 30.0 0.815 264.7 ± 33.8 252.6 ± 20.2 259.3 ± 29.1 0.377
 Midbrain AP diameter (mm) 15.1 ± 1.9 15.0 ± 2.0 0.711 14.9 ± 1.9 16.1 ± 1.9 14.5 ± 1.9 0.017
 Pons AP diameter (mm) 22.77 ± 1.5 14.9 ± 2.0 0.711 15.1 ± 1.8 14.6 ± 1.9 15.1 ± 2.3 0.723
 Pons transverse diameter (mm) 28.4 ± 4.3 26.4 ± 3.4 0.394 26.9 ± 2.5 29.4 ± 3.1 24.4 ± 3.0 0.001
 Cerebellar height (mm) 55.5 ± 3.3 47.1 ± 6.1 0.000 48.4 ± 50 47.8 ± 6.4 45.6 ± 6.7 0.152
 Cerebellar volume (ml) 117.6 ± 13.7 82.7 ± 16.6 0.192 83.4 ± 16.6 84.9 ± 16.2 78.8 ± 16.5 0.217
Correction for cranial sizea
 Corrected Midbrain AP diameter 0.083 ± 0.010 0.081 ± 0.011 0.417 0.081 ± 0.010 0.089 ± 0.011 0.078 ± 0.011 0.002
Corrected Pons AP diameter 0.126 ± 0.008 0.083 ± 0.011 0.417 0.082 ± 0.010 0.081 ± 0.013 0.081 ± 0.011 0.928
 Corrected Pons transverse diameter 0.157 ± 0.024 0.144 ± 0.024 0.406 0.146 ± 0.015 0.163 ± 0.020 0.131 ± 0.018 0.001
 Corrected Cerebellar height diameter 0.306 ± 0.023 0.256 ± 0.038 0.005 0.264 ± 0.030 0.265 ± 0.042 0.245 ± 0.040 0.061
 Corrected Cerebellar volume diameter 0.65 ± 0.06 0.49 ± 0.09 0.011 0.46 ± 0.09 0.47 ± 0.09 0.42 ± 0.09 0.100
Disease duration (years) --- 7.6 ± 6.4   10.5 ± 8.0 8.2 ± 4.6 4.1 ± 2.7 0.001
ICARS score
 Total score --- 36.7 ± 15.3   35.7 ± 12.1 31.4 ± 11.3 40.5 ± 19.0 0.206
 Domain I --- 15.0 ± 7.3   13.7 ± 6.4 10.7 ± 5.5 18.5 ± 7.6 0.001
 Domain II --- 16.5 ± 8.5   16.4 ± 6.3 15.4 ± 6.6 17.11 ± 1.1 0.800
 Domain III --- 3.21 ± 0.5   2.9 ± 1.1 3.2 ± 1.7 3.4 ± 1.7 0.468
 Domain IV --- 1.81 ± 0.3   1.9 ± 1.4 1.8 ± 1.3 1.6 ± 1.3 0.263
  1. SCA indicates spinocerebellar ataxia; CCA, cortical cerebellar atrophy; MSA, multiple system atrophy
  2. a each factor was divided by the cranial AP diameter
  3. b All patients vs. healthy control subjects (unpaired Student’s t-test and χ2 test)
  4. c one-way analysis of variance for the continuous variables and Kruskal-Wallis test for the ICARS score. χ2 test for the male sex distribution