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Table 4 Effect of cerebellar-M1 paired-associative stimulation on primary motor cortex excitability

From: Non-invasive brain stimulation as a tool to study cerebellar-M1 interactions in humans

Authors Sample size Stimulation target(s) Protocol Parameters Sessions Target muscle Coil size Timing of measurements Findings
Lu et al. (2012) [19] 13 HC Right lateral CRB CRB – M1 (PAS2ms) CS: 90 % AMT 120 pairs 0.25 Hz 1 Left FDI CRB: double-cone (110 mm) M1: figure-of-eight (90 mm) Pre/Post 0, 30, 60 min ↑ MEP, ↓SICI CBI, ↔ICF
6 HC As above CRB – M1 (PAS6ms) As above 1 As above As above As above ↓ MEP, ↓SICI CBI, ↔ICF
13 HC As above CRB – M1 (PAS10ms) As above 1 As above As above As above ↓ MEP, ↓SICI CBI, ↔ICF
9 HC As above CRB – M1 (PAScontrol random 2, 6, 10 ms) As above 1 As above As above As above ↔ MEP, SICI, CBI, ICF
  1. CBI cerebellar brain inhibition, CRB cerebellum, FDI first dorsal interosseous, HC healthy controls, ICF intracortical facilitation, M1 primary motor cortex, MEP motor evoked potential, PAS paired-associative stimulation, SICI short interval intracortical inhibition