Non-invasive brain stimulation as a tool to study cerebellar-M1 interactions in humans

Table 4 Effect of cerebellar-M1 paired-associative stimulation on primary motor cortex excitability

Authors	Sample size	Stimulation target(s)	Protocol	Parameters	Sessions	Target muscle	Coil size	Timing of measurements	Findings
Lu et al. (2012) [19]	13 HC	Right lateral CRB	CRB – M1 (PAS_2ms)	CS: 90 % AMT 120 pairs 0.25 Hz	1	Left FDI	CRB: double-cone (110 mm) M1: figure-of-eight (90 mm)	Pre/Post 0, 30, 60 min	↑ MEP, ↓SICI CBI, ↔ICF
	6 HC	As above	CRB – M1 (PAS_6ms)	As above	1	As above	As above	As above	↓ MEP, ↓SICI CBI, ↔ICF
	13 HC	As above	CRB – M1 (PAS_10ms)	As above	1	As above	As above	As above	↓ MEP, ↓SICI CBI, ↔ICF
	9 HC	As above	CRB – M1 (PAS_control random 2, 6, 10 ms)	As above	1	As above	As above	As above	↔ MEP, SICI, CBI, ICF

CBI cerebellar brain inhibition, CRB cerebellum, FDI first dorsal interosseous, HC healthy controls, ICF intracortical facilitation, M1 primary motor cortex, MEP motor evoked potential, PAS paired-associative stimulation, SICI short interval intracortical inhibition

ISSN: 2053-8871