Skip to main content

Table 2 Patient characteristics by clusters

From: Stratification of disease progression in a broad spectrum of degenerative cerebellar ataxias with a clustering method using MRI-based atrophy rates of brain structures

  Total
(n = 48)
Cluster 1
(n = 12)
Cluster 2
(n = 22)
Cluster 3
(n = 14)
p value
Age at the first MRI (years) 60.5 ± 11.3 66.3 ± 8.5 60.4 ± 12.0 56.0 ± 10.6 0.088
Sex (Male/Female) 24/24 7/5 8/14 9/5 0.211
Diagnosis
 SCA, n (%) 21 (43.8) 6 (50.0) 11 (50) 4 (28.6) 0.007
  SCA1 3 0 3 0  
  SCA2 3 1 1 1  
  SCA3 4 0 1 3  
  SCA6 6 2 4 0  
  SCA31 1 1 0 0  
  SCA (unknown) 4 2 2 0  
 MSA-C, n (%) 17 (35.4) 0 (0.0) 9 (40.9) 8 (57.1)  
 CCA, n (%) 10 (20.8) 6 (50.0) 2 (9.1) 2 (14.3)  
ICARS score at the first visit 35.5 ± 16.5 39.1 ± 7.4 35.2 ± 22.2 30.0 ± 16.1 0.464
Initial cerebellar volume index (Vdx) 0.47 ± 0.09 0.45 ± 0.08 0.45 ± 0.10 0.50 ± 0.07 0.275
Annual atrophy volume in Vdx −0.04 ± 0.02 0.02 ± 0.01* −0.04 ± 0.01 −0.07 ± 0.02 0.001
Initial callosal area index (Adx) 3.38 ± 0.45 3.13 ± 0.39 3.53 ± 0.37 3.28 ± 0.46 0.011
Annual atrophy area in Adx −0.11 ± 0.08 −0.04 ± 0.03 −0.10 ± 0.05 −0.19 ± 0.09 0.001
Annual increase in ICARS score 4.4 ± 4.5 2.9 ± 1.7 4.8 ± 3.2 8.7 ± 6.1 0.014
  1. Vdx cerebellar volume index, ICARS International Cooperative Ataxia Rating Scale
  2. *Cluster 1 vs. Cluster 2, p < 0.05, Cluster 1 vs. Cluster 3, p < 0.05
  3. Cluster 1 vs. Cluster 2, p < 0.05
  4. Cluster 1 vs. Cluster 2, p < 0.05, Cluster 1 vs. Cluster 3, p < 0.05, Cluster 2 vs. Cluster 3, p < 0.05 (post-hoc Dunnett’s test)