Skip to main content

Table 1 Classification of immune-mediated cerebellar ataxias (IMCAs)

From: Immune-mediated cerebellar ataxias: from bench to bedside

1. Autoimmunity targeting mainly the cerebelluma or related structuresb:
 Cerebellar autoimmunity triggered by another disease or condition:
  Gluten ataxia (gluten sensitivity)
  Acute cerebellitis (infection)
  Miller Fisher syndrome (infection)
  Paraneoplastic cerebellar degenerations (neoplasm)
 Cerebellar autoimmunity not triggered by another disease or condition:
  Anti-GAD65 Ab-associated cerebellar ataxias c
  Steroid-responsive IMCAs with anti-thyroid antibodies
  Primary autoimmune cerebellar ataxia (PACA)
2. Autoimmunity that targets various parts of the CNS simultaneously:
 Multiple sclerosis
 Ataxia in the context of connective tissue diseases such as systemic lupus erythematosus
  1. Modified from our consensus paper [2]
  2. a When cerebellar deficits are the sole or main symptoms, the cerebellum is presumed to be the main target of autoimmunity
  3. b Involvement of the proprioceptive spinocerebellar pathway is assumed in Miller Fisher syndrome
  4. c Excluding paraneoplastic patients