Our scope in a rapidly changing discipline, which is now recognized
The neuroscientists and clinicians working in the field of cerebellar research and ataxiology are living in a fascinating period: the recognition by the scientific community of the specificity of their activity. Neglected for many years, the field of cerebellar ataxias is now evolving as a well-circumscribed neuroscience and clinical discipline. Disorders of the cerebellum present with specific symptoms and signs, have a specific natural course and particular mechanisms in terms of pathogenesis. It can be predicted that most university centers in the world will host an ataxia unit in a decade from now. Indeed, numerous clinical disorders affect the cerebellum at any stage of life, either in an acute or in a chronic way. Cerebellar operations spread from motor to cognitive and behavioral aspects [1, 2]. With its unique geometrical structure, the region of the brain containing the most numerous neurons is more than ever a topic of interest. Indeed, cerebellum maps to cerebral association networks in a highly organized manner, mirroring the asymmetries of the cerebral cortex for language and attention . The “little brain” is scrutinized with the hope that it will reveal its numerous secrets, and that these secrets will have numerous applications. Thanks to next generation sequencing techniques, the discoveries in genetics are enriching the basket of cerebellar disorders nearly on a weekly basis. A convergence of molecular discoveries and clinical observations is appearing . However, numerous case descriptions and case series remain unpublished, despite their importance for daily clinical care, or their relevance for building clinically-relevant models and the successful implementation of personalized molecular medicine tailored to individuals . We aim to attract these reports, for the benefit of all the community. And the patients themselves.
Cerebellum and Ataxias will consider not only scientific reports, but also clinical cases of the numerous forms of ataxias affecting children and adults. Case reports and clinical series, as well as reviews, commentaries and teaching images with a take-home message will be welcome.